hCaV 1.2

Cav1.2 is the major pore-forming alpha subunit of long-lasting (L-type) voltage-gated Ca²⁺ channels in the heart. The channels are present in the membranes of most excitable cells, where they mediate the entry of Ca²⁺ into cells upon depolarization. Cav1.2-containing channels play an important role in the heart, particularly in modulating ventricular and atrial contraction. The Cav1.2 protein binds to dihydropyridines, a class of drugs used to treat hypertension. Mutations in the CACNA1C gene encoding Cav1.2 have been implicated in long QT syndrome, Brugada syndrome, and bipolar disease