MYOCARDIAL CONTRACTILITY

Cardiac papillaries are rounded or irregular muscular columns which project from the inner surface of the ventricles of the heart and connect to the valves via tendonous projections. Cardiac trabeculae are distinct muscle tracts connecting between different local areas of the inner heart wall, particularly at the apex and septal junctions. Although both may be cut free and used for tension kinetics studies, the trabeculae are most commonly used to represent myocardial contractility for drug studies, both from electrical and mechanical standpoints.

No amount of preclinical testing in other species can guarantee the same results in humans once expensive clinical trials are launched.  AVIVA's contraction studies can indicate whether your preliminary results will be consistent with the human response.

AVIVA scientists measure the profile of trabecular contractions to determine contractility and rhythmicity effects pertaining to drug efficacy, potency, toxicity, and cardiac safety of pharmaceutical compounds.